Research Paper Volume 12, Issue 8 pp 6611—6629

Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis

Figure 1. HO-1 expression is associated with increased Gas6 expression in CD138+ cells from patients with multiple myeloma (MM). (A, B) mRNA expression of HO-1 and Gas6 in human primary CD138+ cells were measured by qRT-PCR. β-actin was used as a control. (C) ELISA assay showed the plasma Gas6 level. *P<0.01 vs. normal group. (DE) A Pearman correlation analysis showed the association between HO-1 mRNA expression level and Gas 6 mRNA level (r=0.927; P<0.001) or Gas6 plasma level (r=0.884; P<0.001).