Research Paper Volume 12, Issue 7 pp 6058—6066

Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway


Figure 1. Aspirin rehabilitated CCl4-induced liver fibrosis and inflammation in rat. (A) Liver fibrosis was detected 6 weeks after CCl4 treatment by HE. (×200; scale bar: 100μm) (B) Hepatic hydroxyproline content was measured 6 weeks after CCl4 treatment. (C, D) Hepatic fibrosis was examined by Sirius red staining. (×200; scale bar: 100μm) (E, F) The AST and ALT were detected to assess the liver function. (GJ) The levels of inflammatory cytokines (IL-6 and TNF-α) in serum and liver tissues were measured by ELISA and real-time PCR. *P<0.05, **P<0.01.