Research Paper Volume 12, Issue 8 pp 6630—6643

γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling

Figure 1. Establishment of mouse OA model (A) Schematic representation of the timeline of chemically induced OA and mangostin treatment regimen. The table describes the treatment conditions. (B) Real-time PCR analysis comparing serum mRNA levels of IL-6, TNF-α, INF- γ and NF-κb before (healthy, day 0) and post OA induction (day 40). It was clear that after OA induction (day-40), the mRNA level of IL-6, NF-kB, TNF-α and INF-γ were significantly higher than un-induced counterparts (day-2).