Research Paper Volume 12, Issue 7 pp 6151—6171

Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Figure 3. RPE65, cathepsin D and GFAP immunostaining in Abca4-/- Rdh8-/- mice of different ages. Pictures showing retinal cryosections of 2-month-old (A, C, E) and 18-month-old (B, D, F) mice captured in bright field (left pictures) or after immunostaining for cathepsin D (A, B), RPE65 (C, D) and GFAP (E, F). OS: outer segment; ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer.