Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Valérie Fontaine; Elodie Monteiro; Mylène Fournié; Elena Brazhnikova; Thinhinane Boumedine; Cécile Vidal; Christine Balducci; Louis Guibout; Mathilde Latil; Pierre J. Dilda; Stanislas Veillet; José-Alain Sahel; René Lafont; Serge Camelo

doi:doi:10.18632/aging.103014

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Research Paper Volume 12, Issue 7 pp 6151—6171

Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Figure 3. RPE65, cathepsin D and GFAP immunostaining in Abca4^-/- Rdh8^-/- mice of different ages. Pictures showing retinal cryosections of 2-month-old (A, C, E) and 18-month-old (B, D, F) mice captured in bright field (left pictures) or after immunostaining for cathepsin D (A, B), RPE65 (C, D) and GFAP (E, F). OS: outer segment; ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer.