Research Paper Volume 12, Issue 7 pp 6191—6205

Long non-coding RNA TPT1-AS1 promotes angiogenesis and metastasis of colorectal cancer through TPT1-AS1/NF90/VEGFA signaling pathway

Figure 1. The expression of TPT1-AS1 in CRC and the relationship between TPT1-AS1 expression and prognosis. (A) and (B) qRT- PCR was used to detect the expression of TPT1-AS1 in CRC tissues and corresponding normal tissues. (C) Relative TPT1-AS1 expression was examined in CRC tissues from patients of different stages. (D) TPT1-AS1 expression was measured in different CRC cell lines using qRT-PCR. Kaplan-Meier plotter was used to analyze the overall survival (E) and disease-free survival (F) of patients in TPT1-AS1 high/low groups. (G) TPT1-AS1 expression pattern in patients of different stages in TCGA database. (H) TCGA data was analyzed to obtain the overall survival of patients from TPT1-AS1 high or low groups. *P < 0.05, **P < 0.01, ***P < 0.001, # represents no statistical significance.