Research Paper Volume 12, Issue 7 pp 6292—6305

Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Figure 5. Influences of flavonoids in A. conyzoides on liver and kidney function, and the biochemical indexes of inflammation in mice. (A) Compared to the control group, various doses of flavonoids in A. conyzoides did not significantly affect the serum levels of ALT (a biomarker of hepatic function), Cr and Bun (biomarkers of kidney function) in mice. While the serum level of AST (another biomarker of hepatic function) was significantly decreased by various doses of flavonoids in A. conyzoides (*P<0.05, compared to control). (B) The number of white blood cell (WBC) was reduced by flavonoids in A. conyzoides in a dose-dependent manner (*P<0.05, compared to control). (C) Flavonoids in A. conyzoides at 5 and 10 mg/mL significantly decreased the serum levels of two biochemical indexes of inflammation namely procalcitonin (PCT) and C-reactive protein (CRP) in mice (*P<0.05, compared to control). (D) Flavonoids in A. conyzoides at 5 or 10 mg/mL significantly reduced the serum levels of two pro-inflammation cytokines namely IL-6 and IL-10 in mice (*P<0.05, compared to control).