Research Paper Volume 12, Issue 7 pp 6324—6339

Anterior thalamic nucleus stimulation protects hippocampal neurons by activating autophagy in epileptic monkeys


Figure 7. ANT-DBS increased the colocalization of LC3 and LAMP1 in the hippocampal neurons of epileptic monkeys. Colocalization of LC3 and LAMP-1 was decreased in hippocampal CA1 (A) and CA3 (C) neurons in EP and EP-sham-DBS groups, and increased by ANT-DBS. Colocalization number of LC3 and LAMP-1 in hippocampal CA1 (B) and CA3 (D) neurons. (n=3 in each group; in each monkey, a total of thirty cells in CA1 or CA3, the average immunofluorescent intensity of these cells was recorded) **P < 0.01; ***P < 0.001; NS, P > 0.05. Data were presented as mean ± SD.