FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer

Libin Ma; Huadong He; Kang Jiang; Peiwu Jiang; Han He; Shengjia Feng; Kean Chen; Jia Shao; Gang Deng

doi:doi:10.18632/aging.103030

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Research Paper Volume 12, Issue 7 pp 6352—6369

FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer

Figure 2. FAM46C was a prognosis factor in prostate cancer patients. (A) FAM46C expression was associated with survival outcome in several cancer types from Kaplan Meier-plotter database. (B) FAM46C protein expression levels in prostate cancer tissues from hospital cohort were measured by immunohistochemistry. Scale bars: 100 μm. (C) Kaplan-Meier curves indicated that overall survival of prostate cancer patients from hospital cohort was associated with FAM46C expression level. (D) Univariate and multivariate analysis of overall survival in prostate cancer patients.