Research Paper Volume 12, Issue 7 pp 6352—6369

FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer

Figure 6. FAM46C inhibited cell growth of DU145 cells via the PTEN/AKT signaling pathway. After DU145 cells were transduced with pLVX-Puro-FAM46C with or without SF1670 or IGF-1, the cell proliferation (A, B), cell cycle (C), cell apoptosis (D) and expression of PTEN, P27, cleaved Caspase-3, AKT and p-AKT (E, F) were measured by CCK-8, colony formation, flow cytometry and western blot, respectively. **P<0.01, ***P<0.001 compares with vector; ###P<0.001 compared with FAM46C.