Research Paper Volume 12, Issue 7 pp 6352—6369

FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer

Figure 7. The correlation between FAM46C and PTEN. (A) Co-IP showed that FAM46C interacted with PTEN in DU145 cells. (B) PTEN was immunoprecipitated and immunoblotted in DU145 cells with 10 μM MG132 treatment and pLVX-Puro-FAM46C or blank pLVX-Puro transduction. (C) PTEN protein expression in prostate cancer tissues and noncancerous prostate tissues from hospital cohort were measured by immunohistochemistry. Scale bars: 100 μm. (D) Linear regression showed that FAM46C protein expression was positively correlated with that of PTEN (n=15).