**Figure 3.** **Dysfunctional mitochondria in low-CPT1C-expressing senescent vector PANC-1 cells.** (**A**) ATP production in senescent vector PANC-1 cells, the magnitude of this difference increased as the time in PBS was extended to 24 h. Data are presented as the mean ± S.E.M, n = 4 (***p* < 0.01, ****p* < 0.001). (**B**) Loss of mitochondrial transmembrane potential measured by the rh123 dequenching method in senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 4 (***p* < 0.01). (**C**) Mitochondrial integrity in the forms of OCRs (pMol O_{2}.min^{-1}) in senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 3. (**D**) Maximal respiration capacity in the form of OCRs in senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 3 (***p* < 0.01). (**E**) Spare respiratory capacity in the form of OCRs in senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 3 (****p* < 0.001). (**F**) Mitochondriogenesis analysis in senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 3 (**p* < 0.05, ****p* < 0.001). (**G**) The mitochondrial network structure integrity analysis on the senescent cells. Data are presented as the mean ± S.E.M, n = 3 (****p* < 0.001). (**H**) Mitochondrial autophagy analysis on the senescent cells. Data are presented as the mean ± S.E.M, n = 3 (***p* < 0.01, ****p* < 0.001). (**I**) Mitochondriogenesis analysis on senescent vector PANC-1 cells gaining of CPT1C function. Data are represented as mean ± S.E.M, n = 4 (*p< 0.05). See also Supplementary Figure 4.