**Figure 5.** **Malignance is reduced in low-CPT1C-expressing senescent vector PANC-1 cells.** Sensitivity to metabolic stress from (**A**) glucose deprivation (0.5 mM glucose) and (**B**) glycolytic inhibition (20 mM 2-deoxyglucose) of senescent vector PANC-1 cells at the indicated time points. Data are presented as the mean ± S.E.M, n = 5 (**p* < 0.05, ***p* < 0.01, ****p* < 0.001). (**C**) Sensitivity to metabolic stress from rapamycin stimuli of senescent vector PANC-1 cells at the indicated concentrations. Data are presented as the mean ± S.E.M, n = 5 (***p* < 0.01, ****p* < 0.001). (**D**) Transwell migration and Matrigel invasion capacities of senescent vector PANC-1 cells. Data are presented as the mean ± S.E.M, n = 3 (**p* < 0.05, ***p* < 0.01). (**E**) Tumor sizes are presented as the mean ± S.E.M over time, (n = 5) (***p* < 0.01, ****p* < 0.001). (**F**) Images of tumors after excision on day 42 post-implantation. (**G**) Comparison of dissected tumor weights (mean ± S.E.M, ****p* < 0.001). See also Supplementary Figure 5.