Figure 2. Spermidine and spermine ameliorates cognitive dysfunction in behavioral test in SAMP8. (A, B) Discrimination index and paths in novel object recognition. (C) The modified number in open field test. (D) The distance of inner squares in open field test. (E) Time spent in the inner squares in open field test. (F) The paths of respective groups. Data represent mean ± SEM (n = 10 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.