Research Paper Volume 12, Issue 7 pp 6401—6414

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Figure 6. Spermidine and spermine phosphorylate AMPK and inducing autophagy in SAMP8. (A) The western blot of autophagy protein. (B) The expression of P-AMPK in the brain. (C) The expression of Beclin in the brain. (D) The expression of p62 in the brain. (E) The expression of LC3 in the brain. Data represent mean ± SEM (n = 3 per group). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. SAMR1; *P < 0.05, **P < 0.01, ***P < 0.001 vs. SAMP8.