Research Paper Volume 12, Issue 8 pp 6852—6864

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Figure 5. Exercise training inhibited components of FAS-dependent and mitochondrial-dependent apoptotic pathways activation in hippocampus of D-galactose-induced aging rats. (A) The representative protein levels of FAS ligand, activated FAS receptor, FADD, activated Caspase 8. (B) Bad, Cytochrome C, Caspase 9 and (C) Caspase 3 prepared from hippocampal homogenates in the control, exercise, aging and aging with exercise rats were measured by Western blotting analysis (n=3). The protein expression folds were normalized with β-actin. * P <0.05, **P<0.01, ***P<0.001, significant differences from the control group. ##P <0.05, ###P <0.01, ###P<0.001.significant differences from the D-galactose-induced aging group.