Research Paper Volume 12, Issue 8 pp 6904—6927

Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6

Figure 1. UAP1L1 was upregulated in gastric cancer tissues and gastric cancer cells. (A) The expression level of UAP1L1 was detected by IHC analysis in gastric cancer tissues and normal tissues (scale bar = 50 μm). (B) The mining of RNA-seq data of TCGA showed the upregulated mRNA expression of UAP1L1 in tumor tissues of gastric cancer patients compared with that in normal tissues. (C) The mining of prognosis data of KM plotter showed the significantly association between UAP1L1 high expression and shorter survival period of gastric cancer patients. (D) The mRNA expression of UAP1L1 in GES-1, BGC-823, SGC-7901, AGS and MGC-803 cell lines was detected by qPCR. The representative images were selected from at least 3 independent experiments. Data was shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.