Research Paper Volume 12, Issue 8 pp 7015—7029

Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice

Figure 1. Quercetin improves learning and memory impairment in db/db mice. (A) The chemical structure of Quercetin. (B) Escape latency of the five day in MWM. (C) Swimming paths of the db/db mice on the first and fifth day in MWM. (D) Time spent in the target quadrant in in MWM. (E) Crossing times of the target platform in MWM. (F) Novel object preference index in NOR. Quercetin-L: 35mg/kg/d; Quercetin-H: 70mg/kg/d. Data represent mean ± SEM (n = 10 per group). #p < 0.05, ##p < 0.01, ###p < 0.001vs. db/m; * p < 0.05, ** p < 0.01, *** p < 0.001 vs. db/db.