Research Paper Volume 12, Issue 8 pp 7183—7206

Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Figure 7. Identification of the gene signature for KEAP1-mutated LUAD. (A) Bar chart showing the top significant biological processes identified by GO analysis of 36 differentially-methylated genes using the DAVID webtool. (B) Bar chart showing the pathways with the top scores identified by KEGG pathway analysis of 36 differentially-methylated genes using the enrichr webtool. (C) Protein-protein interaction network analysis of the potential 9-gene signature predicting the functional correlation of the KEAP1–NRF2 axis with genes involved in drug metabolism and glutathione metabolic pathways in LUAD.