Research Paper Volume 12, Issue 8 pp 7183—7206

Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Figure 9. Eight-gene signature predicts poor survival in three independent cohorts. (A) Box plots showing the expression differences of the 8-gene signature in low (green) and high (red) risk groups of TCGA–LUAD patients (y-axis, gene expression value of each gene). (B) Kaplan-Meier survival plots showing that high expression of the 8-gene signature was associated with poor survival in TCGA–LUAD patients. (C) Rousseaux (GSE30219) cohort. (D) Bild Nevins Lung (GSE3141) cohort. Red, high-risk group; green, low-risk group; top right corner inset, numbers of high- and low-risk samples (+, numbers of censored samples) and concordance index (CI) of each risk group (x-axis, time (months); y-axis, overall survival probability; HR, hazard ratio; Conf.Int. confidence interval).