Research Paper Volume 12, Issue 8 pp 7334—7349

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway

Figure 6. Combined administration of IF peptide and exercise show better regulation in the molecular events of cell survival and apoptosis. The levels of survival and apoptosis protein such as pAkt, Bax, Cyto C and caspase 3 in different groups (n=6) of aging SAMP 8 mice (A) heart and (B) liver. All protein samples from each rat group were analyzed by Western blotting. The protein expression folds were normalized with β-actin. C: Control; HF: High-fat diet; EX: Exercise; HF+IF: High-fat diet+IF; HF+EX: High-fat diet+ Exercise; HF+EX+IF: High-fat diet+ Exercise+ IF. Bars indicate the mean ± SEM obtained from experiments performed in triplicate. *P<0.05, **P<0.01, ***P<0.001 compared with the control group, #P<0.05, ##P<0.01, ###P<0.001 compared with the HF group.