Research Paper Volume 12, Issue 8 pp 7334—7349

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway

Figure 8. Combined treatment with IF peptide and swimming exercise provide better cardiac and liver rejuvenation potential against HFD effects by enhancing pAMPK/ SIRT1/ PGC-1α/ pFOXO3 protein expression in SAMP8 aging model. The levels of survival and apoptosis protein such as pAMPK/ SIRT1/ PGC-1α/ pFOXO3 in aging rat (A) heart and (B) liver tissue. C: Control; HF: High-fat diet; EX: Exercise; HF+IF: High-fat diet+IF; HF+EX: High-fat diet+ Exercise; HF+EX+IF: High-fat diet+ Exercise+ IF. Bars indicate the mean ± SEM obtained from experiments performed in triplicate. *P<0.05, **P<0.01 compared with the control group, #P<0.05, ##P<0.01, ###P<0.001 compared with the HF group.