Research Paper Volume 12, Issue 8 pp 7363—7379

Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma

Figure 1. NUDT1 is overexpressed in HCC tissues. (A) NUDT1 mRNA levels in HCC and normal liver tissues in TCGA and GEO datasets. Note: TCGA dataset (tumor = 370; normal = 50); GSE14323 (tumor = 55; normal = 60); GSE14520 (tumor = 225; normal = 220); GSE41804 (tumor = 20; normal = 20); GSE45436, (tumor = 93; normal = 41); GSE51401 (tumor = 30; normal = 34); GSE62232 (tumor = 81; normal = 10); GSE6764 (tumor = 35; normal = 40). (BE) Density plot shows the relationship between NUDT1 mRNA expression and clinicopathological characteristics, such as, tumor pathology stage (tumor PT), tumor grade, AJCC tumor stage, and degree of vascular invasion. As shown, high NUDT1 mRNA expression is associated with poor prognosis for patients with HCC belonging to stage IV, G4, macrovascular invasion, and T4. (F) Quantitative RT-PCR analysis of NUDT1 mRNA expression in 16 pairs of HCC and adjacent normal liver tissues is shown. NUDT1 is overexpressed in HCC tissues compared with adjacent normal liver tissues (ANLTs; P < 0.01).