Research Paper Volume 12, Issue 8 pp 7363—7379

Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma

Figure 3. Construction and calibration of the new prognostic nomogram to estimate 5-year survival of HCC patients using NUDT1 as a novel liver-specific variable. (A) Details of the nomogram for predicting survival rates of HCC patients. The corresponding risk score of each clinical variable included in the nomogram is as listed. NUDT1 is the novel liver-specific variable in this nomogram. The C-index of the nomogram was 0.709. (B) The calibration plot shows the differences between true and predicted values of 5-year OS. (C) ROC curve analysis shows the accuracy of the novel prognostic model and other prognostic parameters. The area under curve (AUC) for the prognostic model, AJCC tumor stage, Child-Pugh classification, and tumor grade are 0.740, 0.657, 0.529, and 0.514, respectively. This shows that the prognostic model is more accurate in predicting overall survival by including NUDT1 expression as one of the parameters.