Research Paper Volume 12, Issue 8 pp 7380—7396

Activated CD4+ T cells-derived exosomal miR-142-3p boosts post-ischemic ventricular remodeling by activating myofibroblast

Figure 6. Activated CD4+ T cells promoted cardiac remodeling via exosomal miR-142-3p-APC-WNT signal axis. The work model illustrated the action modality of CD4+ cells-derived exosomes in myofibroblast activation post-MI. Myocardial infarction induced the accumulation of CD4+ T cells into myocardial tissue. Consequently, activated CD4+ cells-derived exosomes facilitated CFs transformation through exosomal miR-142-3p-APC-WNT signal axis.