Figure 4. TPO demonstrated a neuroprotective effect in a neonatal hypoxic-ischemic rat model. Brain injury was estimated using the percentage of the weight reduction in the ipsilateral cerebral hemisphere compared to the contralateral hemisphere. Brain weights of ipsilateral cerebral hemisphere and contralateral hemisphere were measured in the sham-operated, vehicle-treated, and TPO-treated rats at 1 and 3 weeks of hypoxia-ischemia, n = 16. ** P < 0.01.