Research Paper Volume 12, Issue 8 pp 7491—7510

RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

Figure 4. Cellular model of AHL was established by H2O2 exposure. (A) GO-BP analysis showed that oxidative stress and apoptotic processes stimulated the process of AHL. (B) Percent HEI-OC1 cell survival after exposure to increasing concentrations of H2O2 for 24 h, and the IC50 (half maximal inhibitory concentration) of H2O2 was approximately 920 μM (C). Cell viability was detected by RTCA. Cleaved caspase 3 and HO-1 expression in mouse (D) and cellular (E) models of AHL, as determined by Western blotting. *P < 0.05 compared to the control.