miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A

Yong Xu; Wei Jiang; Lili Zhong; Hailun Li; Lin Bai; Xiaoling Chen; Yongtao Lin; Donghui Zheng

doi:doi:10.18632/aging.103160

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Research Paper Volume 12, Issue 11 pp 10235—10245

miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A

Figure 4. miR-195-5p mimics attenuated renal I/R induced oxidative stress and inflammation. miR-195-5p mimics were injected into the rat via the tail vein prior to I/R surgery. The renal tissues were collected at 24 h post I/R surgery followed by evaluation of the concentration of MDA (A) and SOD (B). IL-6 (C) and (D) TNF-α protein levels were analyzed using ELISA. Eight rats were used in each group. Three independent experiments were performed. Error bars represent the mean ± SD of at least three independent experiments. *P < 0.05.