Research Paper Volume 12, Issue 12 pp 11364—11385

Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway

Figure 10. Schematic representation of the mechanism of Sirt1 associated Adriamycin-resistance in DLBCL cells. Mechanistic diagram of the Sirt1--PGC1-α mitochondrial pathway that mediates the chemical resistance of DLBCL cells and blocks the mitochondrial energy metabolism pathway in overcoming Sirt1-mediated drug-resistance.