Research Paper Volume 12, Issue 11 pp 10246—10258

miR-623 suppresses cell proliferation, migration and invasion through direct inhibition of XRCC5 in breast cancer

Figure 2. miR-623 inhibited the expression of cell cycle proteins. The levels of CDK4 and CDK6 in MDA-MB-453 cells (A) and MCF7 cells (C) were detected using western blot assay. The level of CDK4/6 in MDA-MB-453 cells (B) and MCF7 cells (D). GAPDH was the internal control. Relative amounts of proteins normalized to GAPDH were shown. Experiments showing identical results were performed twice. P values were determined using Student’s t-tests. *P<0.05 compared with O-NC. #P<0.05 compared with siNC.