Research Paper Volume 12, Issue 12 pp 11386—11397

Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress

Figure 3. BMSCs improved the morphological changes of thymus and spleen tissues of aging rats. (A) Morphological changes of thymus and spleen tissues were observed through naked eyes; (B) Histological changes of spleen tissue were investigated after HE staining; (C) Histological changes of thymus tissue were investigated after HE staining; (D) Histological changes of thymus tissue was investigated using transmission electron microscopy. White arrows indicate white pulp; Black arrows indicate splenic nodule; Green arrows indicate cortex; Yellow arrows indicate medulla; Red arrows indicate vacuoles in the cytoplasm of epithelial reticular cells.