Research Paper Volume 12, Issue 12 pp 11386—11397

Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress

Figure 4. Influence of BMSCs on the transformation function of spleen lymphocytes and oxidative stress. (A) BMSCs significantly increased the thymus and spleen indexes; (B) BMSCs significantly increased the spleen SI; (C) Remarkable higher ration between CD4+ T cells and lower CD8+ T cells was achieved by BMSCs; (D) Influence of BMSCs on cytokines in the serum; (E) Influence of BMSCs on SOD levels in the tissues; (F) Influence of BMSCs on MDA levels in the tissues; (G) Influence of BMSCs on protein expression of γ-H2AX in the tissues. * P<0.05 compared with the control group; ** P<0.05 compared with the aging model group.