Research Paper Volume 12, Issue 12 pp 11398—11415

Immune profiling reveals prognostic genes in high-grade serous ovarian cancer

Figure 7. Levels of GBP1 and ETV7 expression correlated with overall survival in HGSOC. (A) Representative images of GBP1 expression in HGSOC tissues, visualized at 40× and 200× magnification. (B) Distribution of the immunoreactive score (IRS) in an HGSOC TMA. (C) Kaplan-Meier survival curve with log-rank analysis of overall survival showed statistical significance between the curves of patients with high GBP1 expression and those with low GBP1 expression (log-rank test, p=0.0003). (D) Univariate analysis was performed in 165 HGSOC patients. All bars correspond to 95% confidence intervals. (E) Multivariate analysis was performed in 165 HGSOC patients. All bars correspond to 95% confidence intervals. (F–G) Expression levels of ETV7 and CXCL13 were measured in HGSOC tissues compared with controls. Moreover, Kaplan-Meier method indicated the prognostic significance of ETV7 and CXCL13.