Research Paper Volume 12, Issue 11 pp 10259—10274

Structural plasticity of the bilateral hippocampus in glioma patients

Figure 5. Correlation analysis. (A) Significant negative correlation between age and hippocampal volume in HCs (r = -0.48, p < 0.0001). (B) Significant negative correlation between age and hippocampal volume in the LGG group (r = -0.28, p = 0.04). (C) There was no significant correlation between age and hippocampal volume in the HGG group (r = 0.02, p = 0.91). (D) Kaplan-Meier curves and log rank tests showed that a large hippocampal volume (≥ 6.92 cm3, n = 24) (mean OS: 21.5 months, 95% CI: 18.1-24.9 months) was associated with a shorter OS than a small hippocampal volume (< 6.92 cm3, n = 23) (mean OS: 27.7 months, 95% CI: 25.5-29.8 months) in high-grade glioma patients (n = 47, p = 0.007).