Research Paper Volume 12, Issue 14 pp 14037—14049

Calponin 3 is associated with poor prognosis and regulates proliferation and metastasis in osteosarcoma

Figure 7. CNN3 silencing inhibits tumor growth and lung metastasis in vivo. (A, B) The effect of CNN3 silencing on the growth of subcutaneous xenograft tumors. (A) Subcutaneous xenograft tumor graphs. (B) Tumor growth curve based on the tumor volume. (C) The effect of CNN3 silencing on lung metastases examined by H&E staining. Images on the left are representations. The bar graph showing the statistical evaluation of the number of metastatic foci is on the right. *p<0.05, when LV-shCNN3 vs LV-NC.