Research Paper Volume 12, Issue 12 pp 11446—11465

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Figure 4. miR-9 and miR-29a affect disease manifestation of DM in rats. (A) The expression of FBG, TG, TC, LDL, FFA and HDL in the serum of normal rats and rats with DM following lentiviral infection. (B) HOMA-IR level of normal rats and rats with DM following lentiviral infection. (C) The glucose level of normal rats and rats with DM following lentiviral infection detected by OGTT assay; * p < 0.05 vs. the normal group; # p < 0.05 vs. the DM group; @ p < 0.05 vs. the LV-ISL1 + LV-miR-9 group; & p < 0.05 vs. the LV-ISL1 + LV-miR-29a group. Results were measurement data and expressed as mean ± standard deviation; one way analysis of variance was used to analyze data among multiple groups; n = 8; the experiment was repeated three times independently.