Research Paper Volume 12, Issue 12 pp 11446—11465

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Figure 7. Schematic illustration of the regulatory role of miR-9 and miR-29a in DPN. miR-9 and miR-29a are highly expressed in DM, which inactivate the SHH signaling pathway by binding to ISL1, thereby promoting the occurrence and development of DPN.