Research Paper Volume 12, Issue 11 pp 10337—10358

Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases

Figure 1. Immunohistochemical FAP staining along the adenomatous polyp-cancer sequence of CRC. (A) 68,3% of adenocarcinomas were positively stained. Uninvolved colorectal mucosa and adenomas were negative (x200). (B) FAP staining was scored as negative or positive. The scores were quantified in each tissue type and statistical significance of the FAP expression pattern among the different tissues was determined by Chi-Square test (*** p<0.001). H&E: Hematoxylin and Eosin. FAP: Fibroblast activation protein-α.