Figure 5. Pathway analysis of the differentially-expressed proteins. (A) Pathway analysis of significantly altered metabolites in A549 cells compared with baseline. (B and C) Compound reaction networks of the metabolites and genes were visualized using Metscape: genes (circles), metabolic enzymes (squares) are presented as nodes, and relationships are presented as edges. Input genes are shown in blue, input metabolites are shown in red. The metabolite-gene association network was primarily related to malate-aspartate metabolism.