Research Paper Volume 12, Issue 11 pp 10427—10440

LncRNA PVT1 promotes exosome secretion through YKT6, RAB7, and VAMP3 in pancreatic cancer

Figure 6. PVT1 stimulates exosome secretion via palmitoylation of YKT6. (A) The level of palmitoylation of YKT6 in PVT1-overexpressing HS766T cells. (B) The level of palmitoylation of YKT6 in PVT1-overexpressing HS766T cells treated with Digitonine (control) or Triton X-100 (palmitoylation inhibitor). (C) The concentration of exosomes derived from PVT1-overexpressing HS766T cells treated with Digitonine (control) or Triton X-100 (palmitoylation inhibitor). *P < 0.05, data are expressed as the mean ± SD.