Research Paper Volume 12, Issue 11 pp 10457—10472

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Figure 6. EA modulated the Nrf2 and TLR4 signaling pathways. (A) and (C) The levels of Nrf2, HO-1, TLR4, MyD88, p-IκBα and NF-κB p65 in the hippocampus were detected by Western blot. (B) and (D) Band intensities were quantified as percentages of values from the control group. Data values were expressed as the mean ± SEM (n=3), #P < 0.05 and ##P < 0.01 vs. control group; *P < 0.05 and **P < 0.01 vs. SD group.