Research Paper Advance Articles

Age-related cognitive decline in baboons: modeling the prodromal phase of Alzheimer's disease and related dementias

Figure 1. CANTAB touch task 1 detects age-associated differences in learning novel tasks. (A) Photograph depicting the baboon touching the stimulus displayed on the CANTAB screen. (B) Baboon retrieving the fruit pellet from the dispenser following a correct response on the task. (C) Daily performances demonstrated that adult baboons learned the task quicker and scored more correct responses than the aged ones. (D) The difference in performance in correct response was significantly different (Two-way ANOVA, ** p<0.05 Vs. adult). (E) The aged baboons took significantly more time to reach the criterion compared to the adult animals. The latencies to respond (F and G) and to collect pellets from the dispenser (H and I) were significantly slow in aged subjects.