Research Paper Volume 12, Issue 11 pp 10527—10543

Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis

Figure 3. LncRNA-H19 in HAMSCs promotes osteogenesis in vivo. (A) NC, H19, shNC and shH19 groups were transplanted subcutaneously into a rat critical-sized mandibular defect model for 8 weeks. (B) Reconstructed 3D micro-CT images of the tissue-engineered bone and percentages of BV/TV. (C) H&E staining, Masson staining and immunohistochemical staining of RUNX2 in NC, H19, shNC and shH19 groups. b: bone-like tissues, h: HA/TCP scaffold, f: fibrous. Scale bar, 200 μm. Data are shown as mean ± SD. **P < 0.01.