Research Paper Volume 12, Issue 11 pp 10594—10613

Coagulation factor 2 thrombin receptor promotes malignancy in glioma under SOX2 regulation

Figure 1. F2R is significantly upregulated in glioma and predicts poor survival. (A) Analysis of the expression pattern of F2R in normal brain and glioblastoma tissue, based on the Oncomine database of Sun, TCGA, Bredel and Liang glioblastoma datasets. (B) Western blotting detection of the F2R expression in 6 pairs of malignant glioma and normal tissues. (C) Western blotting detection of the F2R expression in normal human brain cells and three glioma cell lines. (D) The expression of F2R in normal tissue and malignant glioma tissues using the Human Protein Atlas database. (E) F2R was significantly associated with overall survival in glioma patients, using a Kaplan–Meier curve and a log-rank test. GBM, Glioblastoma multiforme; LGG, Brain Lower Grade Glioma. Data are presented as the mean ± SEM.