Research Paper Volume 12, Issue 11 pp 10614—10632

Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways

Figure 3. Effect of UA on the expression of NOX4 in mice with liver fibrosis. (A) The effect of UA on NOX4 expression was determined by using IHC. (B) Hepatic mRNA levels of NOX4 were measured by qRT-PCR. (C) Hepatic protein levels of NOX4 were detected by a western blot. (D) Detection of MDA content in the liver by a commercial kit. Data represent the mean ± SD of each group. *P < 0.05 and ***P < 0.001.