Research Paper Volume 12, Issue 11 pp 10614—10632

Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways

Figure 4. Effect of UA on the expression of RhoA/ROCK1 in liver fibrotic mice. (A) The effect of UA on RhoA/ROCK1 expression was determined by using IHC. (B) Hepatic mRNA levels of RhoA/ROCK1 were measured by qRT-PCR. (C) Hepatic protein levels of RhoA/ ROCK1 were detected by a western blot. Data represent the mean ± SD of each group. *P < 0.05 and ***P < 0.001.