Research Paper Volume 12, Issue 11 pp 10614—10632

Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways

Figure 5. The effect of UA on CCl4-induced liver injury and fibrosis is related to RhoA. (A) HE staining (100× magnification). (B) Masson’s trichrome staining (100× magnification). (CD) Morphometrical analysis of the fibrotic score and fibrotic area. (E) Detection of the hydroxyproline content in liver tissue by colorimetry. (F) Liver function indices in mouse sera. Data represent the mean ± SD of each group. *P < 0.05 and ***P < 0.001.