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Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

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Figure 5. Knockout of the Src gene alleviates cerebral infarction, and improves neuron functions and learning and memory abilities in MCAO mice. (A) neurological function score of Src-/- mice. (B) rate of left limb fault step in Src-/- mice in the foot-fault test; (C) latency period and number of errors of Src-/- mice during the step-down test; (D) the volume of infarct in Src-/- mice after TTC staining; (E) the number of neurons in Src-/- mice using Nissl staining (× 400). Measurement data are expressed as mean ± standard deviation and compared using one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.