Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 6. Knockout of Src gene restricts oxidative stress and the expression of inflammatory markers in the brains of MCAO mice. (A) ROS content in the brain tissues of Src-/- mice was measured using a DCFH-DA fluorescent probe; (B) TNF-α, IL-1, IL-6, IL-17 and IL-10 expression in the brain tissues of Src-/- mice using ELISA. Measurement data are expressed as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO); N = 15.