Research Paper Volume 12, Issue 11 pp 10912—10930

Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models

Figure 3. Autophagic flux in the brains of APP/PS1 DTg AD mice of ages. (A) Western blot showing LC3, BECN-1, p62 and Lamp1 expression in the brains of wild-type (Wt) and APP/PS1 DTg mice. (BE) Relative gray density analysis of LC3-II/LC3-I, BECN-1, p62, and Lamp1 expression levels. The data are presented as the mean ± SEM and were analyzed by t test. (Compared with Wt mice, * P < 0.05, ** P < 0.01, *** < 0.001; “ns” denotes that there was no significant difference, n=3).