Research Paper Volume 12, Issue 11 pp 10969—10982

P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6

Figure 1. P22077 does not affect cell viability. (A) The chemical structure of P22077. (B, C) The cytotoxicity of P22077 in Raw264.7 cells (B) and mouse peritoneal macrophages (PM) (C). (D) Raw264.7 cells and peritoneal macrophages plated treated by different concentrations of P22077 for 12h, the morphology of the cells observed under the microscope. Scale bars, 100μm. Similar results were obtained from three independent experiments and data were presented as mean ± SD of one representative experiment.